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HIV antigens and T-cell receptor variable beta chain families

Abstract

The authors investigated whether the human immunodeficiency virus (HIV) has restrictive effects on the variable region of the beta chain (V beta) of the T-cell antigen receptor (TCR), by in vitro cultivation of non-HIV-infected peripheral blood lymphocytes with one of six HIV antigens or heat-inactivated whole virus (HIV-HI). Resting and blastic CD4+ and CD8- cells were assessed with 3-colour cytofluorometry and monoclonal antibodies to various V beta families/subfamilies. The V beta families affected include V beta’s 13.1/.3, 8, and 21 with gp 120; V beta 21 with gp 160 and RT; V beta 8 with p25; V beta’s 8 and 21 with Rev; and V beta’s 3 and 21 with HIV-2 Vpx.

V beta family-specific effects with HIV-HI did not differ significantly from those found with IL-2 stimulation. Findings differed between CD4+ and CD8+ cells. For CD4+ lymphocytes, significant V beta-specific decreases were found, not the expansions found with superantigens or mitogens. CD8+ lymphocytes showed slight but significant expansions. The effects on V beta’s 8, 13, and 21 are consistent with previous studies of HIV-infected persons. However, it is difficult to accept that antigens encoded by different HIV genetic regions cause proportionate diminutions of similar V beta families.

 

The authors suggest that these effects may be secondary to changes in cytokine profiles rather than direct interactions with TCR V beta’s.

Jason J, Inge KL, Orloff SL

Scand. J. Immunol. 1997 Jan;45(1):81-90

PMID: 9010504

Jason-1997-Scand-j-Immunol-HIV-antigens
HIV antigens and T-cell receptor variable beta chain families was last modified: October 18th, 2015 by Jason J, Inge KL, Orloff SL