immune development

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Age-related differences in cell-specific cytokine production by acutely ill Malawian patients

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Abstract

Age-related changes in human cell-specific cytokine responses to acute illness have not been well examined. We therefore evaluated age-related differences in T, B and natural killer (NK) peripheral blood lymphocyte cytokine responses of 309 acutely ill hospitalized people in Malawi, Africa, < 1 month-61 years of age.… Read more

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Parenting Your Premature Baby

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Jason J, van der Meer A. Holt Publishing Company, NY, NY, 1989.

Above book was published in paperback by Dell Publishing Company, New York, NY in June, 1990. German publication rights for above book given in 1991.

Parenting Your Premature Baby was cited in the Library Journal as one of the best lay medical books for public libraries (1988-89).… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Infectious disease-related deaths of low birth weight infants, United States, 1968 to 1982

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Abstract

Infant mortality rates in the United States are higher than in any other developed country. Low birth weight (LBW) is the primary determinant of infant mortality.

 

Despite city, state, and federal programs to prevent LBW, decreases in infant mortality in the 1980s appear to be largely secondary to improved survival of LBW infants rather than to a decline in the rate of LBW births.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

An outbreak of necrotizing enterocolitis. Association with transfusions of packed red blood cells

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Abstract

Of 187 newborns admitted to a 33-bed, level III neonatal intensive care unit between January 1, 1985 and June 23, 1985, 33 developed necrotizing enterocolitis during their hospital stay. Twenty of the 33 newborns (61%) had onset of symptoms between April 1 and June 23, suggesting clustering during this period.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Infectious diseases: preventable causes of infant mortality

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Abstract

After almost a century of improvement, the rate of decrease in US infant mortality rates began to level off during the period of 1982 to 1984. Rates actually increased in some states. Because much of the decline in infant mortality in this century can be attributed to advances in infectious disease treatment and prevention programs, we evaluated the current impact of infectious diseases on infant mortality.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

An historical perspective on controversy surrounding the international code of marketing of breast‑milk substitutes

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Jason JM, McGrady GA.

In: Clinical Obstetrics – A Public Health Perspective.  B P Sachs & D Acker (eds).  PSG, Inc. Boston, MA, 1985.

ISBN 0-88416-513-2… Read more

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Mortality and infectious disease associated with infant-feeding practices in developing countries

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Abstract

This review examines the available studies bear­ing on the relation between infant-feeding mode and infectious illness in the populations of less­ developed countries.  In this review we will address the following key questions: (1) whether the method of infant feeding (breast v other) is associated with differences in rates of mortality, both overall and infectious, and in rates of infectious morbidity in less-developed countries; (2) whether differences exist between breast-feeding and other feeding methods in terms of infection rates for specific pathogens; and (3) whether the evidence is strong enough to suggest that any association is a causal one, ie, that the effect noted is actually caused by breast-feeding rather than other factors associated with rates of illness.  … Read more

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In vitro cultivation of nonlymphoid thymic cells: morphological and immunological characterization

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Abstract

Nonlymphoid thymic elements play an important role in T-lymphocyte development, especially in the development of recognition of transplantation antigens (H-2 in the mouse). Understanding this process will require the isolation and characterization of these cells. A simple technique for the culture of an enriched population of murine thymic epithelium is described.… Read more

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Distinctive immunological properties of cultured murine thymic epithelial cells

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Abstract

Skin painting with chemically reactive haptens induces a hapten-specific state of hypersensitivity that is long lasting and can be transferred to unirradiated recipient mice. A similar state of hapten-specific contact sensitivity can be induced by intravenous immunization with hapten-conjugated cells.… Read more

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Detection of a novel binding site for T cell derived antigen binding proteins on thymic epithelial cell surfaces

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Abstract

The presence of helper T cells that do not recognize major histocompatibility complex encoded antigenic determinants but rather are specific for self idiotypic determinants led us to search for a mechanism by which such cells might be influenced by idiotype expressed on the surfaces of thymic epithelial cells.… Read more

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How T lymphocytes recognize antigen

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Abstract

One of the most intriguing problems in immunology during the years since the discovery of T cells as an entity has been the nature and specificity of their receptors. The study of the antigen-binding receptors in T cells has been plagued by a number of technical difficulties that are just now being solved.… Read more

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T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted

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Abstract

We have investigated primary and secondary responses of mouse splenic T cells to strong mixed lymphocyte stimulating antigens controlled by the Mls locus using MHC-identical mixtures of cells. Our studies show that strong primary Mls-locus specific responses involve recognition of self I-A antigens, since BUdR and light suicide or F1 into parent radiation bone-marrow chimeras both demonstrate a preference of unprimed F1 T cells to respond to Mls-locus antigens associated with one parent’s MHC antigens.… Read more