T-lymphocyte development

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In vitro cultivation of nonlymphoid thymic cells: morphological and immunological characterization

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Abstract

Nonlymphoid thymic elements play an important role in T-lymphocyte development, especially in the development of recognition of transplantation antigens (H-2 in the mouse). Understanding this process will require the isolation and characterization of these cells. A simple technique for the culture of an enriched population of murine thymic epithelium is described.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Distinctive immunological properties of cultured murine thymic epithelial cells

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Abstract

Skin painting with chemically reactive haptens induces a hapten-specific state of hypersensitivity that is long lasting and can be transferred to unirradiated recipient mice. A similar state of hapten-specific contact sensitivity can be induced by intravenous immunization with hapten-conjugated cells.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted

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Abstract

We have investigated primary and secondary responses of mouse splenic T cells to strong mixed lymphocyte stimulating antigens controlled by the Mls locus using MHC-identical mixtures of cells. Our studies show that strong primary Mls-locus specific responses involve recognition of self I-A antigens, since BUdR and light suicide or F1 into parent radiation bone-marrow chimeras both demonstrate a preference of unprimed F1 T cells to respond to Mls-locus antigens associated with one parent’s MHC antigens.… Read more