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Acquired immunodeficiency syndrome (AIDS) associated with transfusions

Abstract

Of 2157 patients with the acquired immunode­ficiency syndrome (AIDS) whose cases were
reported to the Centers for Disease Control by August 22, 1983, 64 (3 per cent) with AIDS and
Pneumocystis carinii pneumonia had no recognized risk factors for AIDS. Eighteen of these (28 per
cent) had received blood components within five years before the onset of illness. These patients
with transfusion-associated AIDS were more likely to be white (P = 0.00008) and older (P = 0.0013)
than other patients with no known risk factors. They had received blood 15 to 57 months (median, 27.5) before the diagnosis of AIDS, from 2 to 48 donors (median, 14). At least one high-risk donor was identified by interview or T-cell-subset analysis in each of the seven cases in which investigation of the donors was complete; five of the six high-risk donors iden­tified during interview also had low T-cell helper/suppres­sor ratios, and four had generalized lymphadenopathy according to history or examination. These findings strengthen the evidence that AIDS may be transmitted in blood.

 

Curran JW, Lawrence DN, Jaffe H, Kaplan JE, Zyla LD, Chamberland M, Weinstein R, Lui K‑J, Schonberger LB, Spira TJ, Alexander WJ, Swinger G, Ammann A, Solomon S, Auerbach D, Mildvan D, Stoneburner R, Jason JM, Haverkos HW, Evatt BL

N Engl J Med 1984;310:69‑75

Curran-nejm198401123100201
Acquired immunodeficiency syndrome (AIDS) associated with transfusions was last modified: October 20th, 2015 by Curran JW, Lawrence DN, Jaffe H, Kaplan JE, Zyla LD, Chamberland M, Weinstein R, Lui K‑J, Schonberger LB, Spira TJ, Alexander WJ, Swinger G, Ammann A, Solomon S, Auerbach D, Mildvan D, Stoneburner R, Jason JM, Haverkos HW, Evatt BL