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Transient antibody deficiency and abnormal t-suppressor cells induced by phenytoin


The lack of normal ¬†B-cell ¬†differentiation in patients with acquired or congenital antibody ¬†deficiency may reflect abnormalities inherent in cells of B-lymphoid ¬†lineage or may ¬†involve abnormalities of regulatory (suppressor) cells. Circulating suppressor T cells, ¬†which interfere with IgM secretion in a plaque-forming-cell assay, have been found in 60 per cent of these patients, ¬†but their role in the pathogenesis of the disease is unclear.¬†… Read more