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Precautions for Creutzfeldt-Jakob disease

Abstract

Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal disease of the central nervous system. Premortem diagnosis may or may not be conclusive. Because the etiologic agent is virulent, definition of necessary precautions for medical staff associated with such patients is needed.… Read more

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Transient antibody deficiency and abnormal t-suppressor cells induced by phenytoin

Abstract

The lack of normal ¬†B-cell ¬†differentiation in patients with acquired or congenital antibody ¬†deficiency may reflect abnormalities inherent in cells of B-lymphoid ¬†lineage or may ¬†involve abnormalities of regulatory (suppressor) cells. Circulating suppressor T cells, ¬†which interfere with IgM secretion in a plaque-forming-cell assay, have been found in 60 per cent of these patients, ¬†but their role in the pathogenesis of the disease is unclear.¬†… Read more

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Echovirus type 7 meningitis in young children

Abstract

Clinical and virological features are presented of an epidemic of aseptic meningitis in children caused by echovirus type 7. The majority of patients were younger than 1 year of age. Symptoms varied according to age. The degree of CSF pleocytosis was inversely related to age and was significantly greater in infants 7 months of age and younger than in those older than 7 months.… Read more

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Quantitation of human thymus/leukemia-associated antigen by radioimmunoassay in different forms of leukemia

Abstract

Using a radioimmunoassay, increased levels of a human thymus/leukemia-associated antigen (HThy-L) have been detected in leukemic cells and plasma from most patients with E-rosette-positive acute lymphoblastic leukemia (ALL) and a number of patients with E-rosette-negative ALL, acute myeloblastic leukemia (AML), acute monomyelocytic leukemia (AMML), and acute undifferentiated leukemia (AVL).… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Diagnostic considerations in ataxia-telangiectasia

Abstract

13 children with ataxia-telangiectasia were followed for 6 years. Unlike previously reported cases, these patients had progressive, debilitating neurological disease and slight pulmonary or infectious symptoms. Immunological dysfunction was variable and endocrinological defects were absent. Oculomotor findings, alpha-fetoprotein levels, and the incidence of chromosomal breakage were the most consistent parameters in the diagnosis of the condition.… Read more