The risk of conjugal transmission of the HTLV-III/LAV virus associated with the acquired immunodeficiency syndrome (AIDS) in patients with hemophilia is unknown. To date, only a few instances of proven exposure to HTLV-III have been reported among sexual or family contacts of patients with hemophilia. However, seropositivity to a related virus, HTLV-I, has been reported in spouses in geographic areas with an increased incidence of human T-cell leukemia/lymphoma. As a part of a long-term study of hemophiliacs with lymphadenopathy, we discovered a patient with Christmas disease (factor IX deficiency) who developed lymphadenopathy, immunodeficiency, and evidence of exposure to HTLV-III/LAV. His wife developed similar physical findings eight months later.
Andes WA, Lawrence DN, Jason J
Thromb. Haemost. 1986 Feb;55(1):129-30